Humalog Pen

insulin lispro

By Eli Lilly

What is this medication for?

Insulin is a naturally-occurring hormone made by the pancreas that helps our body use or store the glucose (sugar) it gets from food. For people with diabetes, either the pancreas does not make enough insulin to meet the body's requirements, or the body cannot properly use the insulin that is made. As a result, glucose accumulates in the bloodstream. Insulin injected under the skin helps to lower blood glucose levels.

Having good control of blood glucose levels is the key to reducing the risk of complications of diabetes (e.g., kidney disease, eye problems, nerve problems).

Long-term control of blood glucose levels is an important step in preventing diabetes complications such as stroke, heart disease, and kidney disease. This medication works best for people who are following a proper dietary and exercise plan.

There are many different types of insulin and they are absorbed at different rates and work for varying periods of time. Insulin lispro is a rapid-acting insulin. It takes about 10 to 15 minutes after injection to begin working and has its maximum effect between 30 minutes and 90 minutes. It stops working after 4 to 5 hours. It is used to help control blood glucose (sugar) in people with diabetes (type 1 or 2).

Your doctor may have suggested this medication for conditions other than those listed here. As well, some forms of this medication may not be used for all of the conditions discussed here. If you are not sure why you are using this medication, speak to your doctor. Do not stop using this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does this medication come in?

Humalog Pen® is available as:

  • injectable solution
    • 3 mL prefilled disposable pens (100 units per mL)
Some medications may have other generic brands available. Always ask your doctor or pharmacist about the safety of switching between brands of the same medication.

How should I use this medication?

Your required dose of insulin depends on how much natural insulin your pancreas is producing and how well your body is able to use the insulin. Your doctor or diabetes educator will determine the appropriate dose for you according to various lifestyle factors and the blood glucose values obtained while monitoring your blood glucose.

Your dose of insulin should be injected subcutaneously (under the skin), exactly as instructed by your doctor or diabetes educator. The dose of insulin is measured in units (U). Insulin lispro is injected under the skin within 15 minutes before or immediately after a meal. Longer-acting insulins are often used along with insulin lispro to cover the periods of time between doses of insulin lispro. There are many variations of insulin dosing.

Check to make sure you are injecting the correct insulin and dose, especially if you use other insulin with this medication.

Consult your doctor or diabetes educator for proper instructions for injecting insulin. The best places to inject insulin under the skin are on the upper arm, abdomen area (stomach), buttocks, or thigh. Never inject it into a vein or muscle. Rotate these injection areas in order to prevent thickening of the skin (which can happen if certain skin areas are used more frequently than others).

While using this medication, it is important to monitor your blood glucose level regularly, as directed by your doctor or diabetes educator.

Do not dilute or mix insulin lispro with other insulin or solutions without checking with your doctor first. Some forms of insulin cannot be mixed with insulin lispro, and insulin lispro should not be mixed with other insulins if it is in a cartridge or if it is to be used in an external insulin pump.

Insulin lispro should be clear and colorless. Do not use the insulin if you notice anything unusual in the appearance of the solution.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important to use this medication exactly as prescribed by your doctor. The timing of insulin with respect to your meals is crucial to keeping blood glucose under control and preventing unwanted side effects. If you miss a dose, contact your health care professional for advice.

Keep unopened bottles of insulin in the refrigerator until needed - they may be used until the expiration date on the label. Never allow insulin to freeze. Insulin that is currently in use may be kept at room temperature for 28 days only and then discarded. Do not expose insulin to extremely hot temperatures or to sunlight. Keep insulin out of reach of children.

Who should NOT take this medication?

Do not use this medication if you:

  • are allergic to insulin or any ingredients of the medication
  • have low blood glucose (hypoglycemia)
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The contents of this health site are for informational purposes only. Always seek the advice of your physician or other qualified healthcare provider regarding any questions you may have about a medical condition.

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